Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY

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CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Shares
Additional Paid-In Capital
Accumulated other comprehensive loss
Accumulated Deficit
Balance (in shares) at Dec. 31, 2019   111,798,000      
Balance at Dec. 31, 2019 $ 298,600 $ 746,487 $ 25,394 $ (805) $ (472,476)
Increase (Decrease) in Stockholders' Equity          
Issuance of common shares upon public offerings, net of issuance costs (in shares)   13,333,000      
Issuance of common shares upon public offerings, net of issuance costs 187,732 $ 187,732      
Exercise of warrants (in shares)   1,000      
Exercise of warrants 1 $ 2 (1)    
Exercise of stock options (in shares)   1,593,000      
Shares issued on exercise of stock options and vesting of performance awards and restricted stock units 6,643 $ 10,107 (3,464)    
Share-based compensation 17,454   17,454    
Net loss $ (102,680)       (102,680)
Balance (in shares) at Dec. 31, 2020 126,700,000 126,725,000      
Balance at Dec. 31, 2020 $ 407,750 $ 944,328 39,383 (805) (575,156)
Increase (Decrease) in Stockholders' Equity          
Issuance of common shares upon public offerings, net of issuance costs (in shares)   10,166,000      
Issuance of common shares upon public offerings, net of issuance costs 196,740 $ 196,740      
Exercise of warrants (in shares)   1,434,000      
Exercise of warrants 365 $ 2,102 (1,737)    
Exercise of stock options (in shares)   3,238,000      
Shares issued on exercise of stock options and vesting of performance awards and restricted stock units 23,421 $ 33,073 (9,652)    
Issuance of common shares in conjunction with ESPP program (in shares)   37,000      
Issuance of common shares in conjunction with ESPP program 585 $ 808 (223)    
Share-based compensation 31,243   31,243    
Unrealized loss on available-for-sale securities, net (47)     (47)  
Net loss $ (180,966)       (180,966)
Balance (in shares) at Dec. 31, 2021 141,600,000 141,600,000      
Balance at Dec. 31, 2021 $ 479,091 $ 1,177,051 59,014 (852) (756,122)
Increase (Decrease) in Stockholders' Equity          
Exercise of stock options (in shares) 77,000 383,000      
Shares issued on exercise of stock options and vesting of performance awards and restricted stock units $ 521 $ 5,064 (4,543)    
Issuance of common shares in conjunction with ESPP program (in shares)   285,000      
Issuance of common shares in conjunction with ESPP program 1,912 $ 3,194 (1,282)    
Share-based compensation 32,300   32,300    
Unrealized loss on available-for-sale securities, net (209)     (209)  
Net loss $ (108,180)       (108,180)
Balance (in shares) at Dec. 31, 2022 142,268,000 142,268,000      
Balance at Dec. 31, 2022 $ 405,435 $ 1,185,309 $ 85,489 $ (1,061) $ (864,302)