Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS

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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
shares in Thousands, $ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Revenue:      
Total revenue, net $ 134,030 $ 45,605 $ 50,118
Operating expenses:      
Cost of sales 5,664 1,091 0
Selling, general and administrative 196,371 173,536 97,272
Research and development 44,988 51,139 50,327
Other (income) expense, net (1,523) 574 6,809
Total cost of sales and operating expenses 245,500 226,340 154,408
Loss from operations (111,470) (180,735) (104,290)
Interest income 5,118 529 1,516
Net loss before income taxes (106,352) (180,206) (102,774)
Income tax expense 1,828 760 (94)
Net loss (108,180) (180,966) (102,680)
Other comprehensive loss:      
Unrealized loss on available-for-sale securities, net of tax of nil (209) (47) 0
Comprehensive loss $ (108,389) $ (181,013) $ (102,680)
Basic loss per common share (in dollars per share) $ (0.76) $ (1.40) $ (0.87)
Diluted loss per common share (in dollars per share) $ (0.76) $ (1.40) $ (0.87)
Weighted-average common shares outstanding used in computation of basic loss per share (in shares) 141,915 129,369 118,473
Weighted-average common shares outstanding used in computation diluted loss per share (in shares) 141,915 129,369 118,473
Product revenue, net      
Revenue:      
Total revenue, net $ 103,468 $ 45,488 $ 0
License and collaboration revenue      
Revenue:      
Total revenue, net $ 30,562 $ 117 $ 50,118