Quarterly report pursuant to Section 13 or 15(d)

CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY

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CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Shares
Additional paid in capital
Accumulated Other Comprehensive (Loss) Income
Accumulated Deficit
Balance (in shares) at Dec. 31, 2020   126,725,000      
Balance at Dec. 31, 2020 $ 407,750 $ 944,328 $ 39,383 $ (805) $ (575,156)
Increase (Decrease) in Stockholders' Equity          
Shares issued on exercise of stock options and vesting of performance awards and restricted stock units (in shares)   2,324,000      
Shares issued on exercise of stock options and vesting of performance awards and restricted stock units 15,352 $ 22,097 (6,745)    
Exercise of warrants (in shares)   521,000      
Exercise of warrants 37 $ 734 (697)    
Shared-based compensation 22,666   22,666    
Unrealized gain (loss) on available-for-sale securities 11     11  
Net loss (147,644)       (147,644)
Balance (in shares) at Sep. 30, 2021   129,570,000      
Balance at Sep. 30, 2021 298,172 $ 967,159 54,607 (794) (722,800)
Balance (in shares) at Jun. 30, 2021   128,396,000      
Balance at Jun. 30, 2021 332,257 $ 954,572 51,022 (792) (672,545)
Increase (Decrease) in Stockholders' Equity          
Shares issued on exercise of stock options and vesting of performance awards and restricted stock units (in shares)   1,172,000      
Shares issued on exercise of stock options and vesting of performance awards and restricted stock units 9,074 $ 12,579 (3,505)    
Exercise of warrants (in shares)   2,000      
Exercise of warrants 6 $ 8 (2)    
Shared-based compensation 7,092   7,092    
Unrealized gain (loss) on available-for-sale securities (2)     (2)  
Net loss (50,255)       (50,255)
Balance (in shares) at Sep. 30, 2021   129,570,000      
Balance at Sep. 30, 2021 $ 298,172 $ 967,159 54,607 (794) (722,800)
Balance (in shares) at Dec. 31, 2021 141,600,000 141,600,000      
Balance at Dec. 31, 2021 $ 479,091 $ 1,177,051 59,014 (852) (756,122)
Increase (Decrease) in Stockholders' Equity          
Shares issued on exercise of stock options and vesting of performance awards and restricted stock units (in shares) 77,000 383,000      
Shares issued on exercise of stock options and vesting of performance awards and restricted stock units $ 522 $ 5,064 (4,542)    
Issuance of common shares in conjunction with ESPP program (in shares)   127,000      
Issuance of common shares in conjunction with ESPP program 1,223 $ 1,905 (682)    
Shared-based compensation 25,398   25,398    
Unrealized gain (loss) on available-for-sale securities (675)     (675)  
Net loss $ (82,134)       (82,134)
Balance (in shares) at Sep. 30, 2022 142,110,000 142,110,000      
Balance at Sep. 30, 2022 $ 423,425 $ 1,184,020 79,188 (1,527) (838,256)
Balance (in shares) at Jun. 30, 2022   141,892,000      
Balance at Jun. 30, 2022 423,768 $ 1,180,884 74,004 (1,853) (829,267)
Increase (Decrease) in Stockholders' Equity          
Shares issued on exercise of stock options and vesting of performance awards and restricted stock units (in shares)   218,000      
Shares issued on exercise of stock options and vesting of performance awards and restricted stock units 0 $ 3,136 (3,136)    
Shared-based compensation 8,320   8,320    
Unrealized gain (loss) on available-for-sale securities 326     326  
Net loss $ (8,989)       (8,989)
Balance (in shares) at Sep. 30, 2022 142,110,000 142,110,000      
Balance at Sep. 30, 2022 $ 423,425 $ 1,184,020 $ 79,188 $ (1,527) $ (838,256)