Annual report pursuant to Section 13 and 15(d)

Consolidated Statements of Cash Flows

Consolidated Statements of Cash Flows $ in Thousands	12 Months Ended
Consolidated Statements of Cash Flows $ in Thousands	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Cash flows from operating activities:
Net loss	$ (180,966)	$ (102,680)	$ (88,385)
Adjustments to reconcile consolidated net loss to net cash used in operating activities:
Depreciation of property and equipment	663	82	33
Amortization of intangible assets	2,098	1,289	1,138
Upfront license and milestone expense	10,000	0	0
Share-based compensation	31,243	17,454	7,414
Other, net	903	9,477	14,186
Net changes in operating assets and liabilities:
Accounts receivable, net	(15,415)	(650)	(151)
Inventories, net	(5,644)	(13,927)	0
Prepaid expenses and other current assets	(5,335)	2,559	(1,826)
Non-current assets	247	0	0
Right of use assets	106	(5,489)	0
Accounts payable and accrued liabilities	4,076	13,620	4,006
Lease liabilities	332	8,407	0
Net cash used in operating activities	(157,692)	(69,858)	(63,585)
Cash flows from investing activities:
Proceeds on investments	354,427	52,108	7,884
Purchase of investments	(438,958)	(202,951)	0
Upfront lease payment	(11,838)	0	0
Upfront license payment	(6,000)	0	0
Purchase of long-lived assets	(297)	(5,584)	(85)
Additions to internal use-software implementation costs	(1,198)	(1,675)	0
Capitalized patent costs	(6)	(84)	(16)
Net cash used in investing activities	(103,870)	(158,186)	7,783
Cash flows from financing activities:
Proceeds from issuance of common shares pursuant to Public Offering, net of issuance costs	196,740	187,732	223,118
Proceeds from exercise of share options and employee share purchase plan	24,007	6,642	13,748
Proceeds from exercise of warrants	365	1	6,988
Net cash provided by financing activities	221,112	194,375	243,854
Net (decrease) increase in cash and cash equivalents during the year	(40,450)	(33,669)	188,052
Cash and cash equivalents, beginning of the year	272,350	306,019	117,967
Cash, cash equivalents and restricted cash, end of the year	231,900	272,350	306,019
Supplemental cash flow information:
Cash paid for legal settlement	0	0	(100)
Cash received for interest	749	1,884	2,619
Cash paid for taxes	(257)	(261)	(59)
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets
Cash, cash equivalents	231,643	272,350	306,019
Restricted cash	257	0	0
Total cash, cash equivalents and restricted cash	$ 231,900	$ 272,350	$ 306,019