Annual report pursuant to Section 13 and 15(d)

Shareholders' Equity - Anticipated and Actual Use of Proceeds (Details)

v3.20.4
Shareholders' Equity - Anticipated and Actual Use of Proceeds (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Class of Stock [Line Items]    
Total net proceeds from financings $ 573,143  
Net proceeds used to date   $ 249,706
March 2017 Offering    
Class of Stock [Line Items]    
Total net proceeds from financings 162,324  
Net proceeds used to date   162,324
March 2017 Offering | Research and Development Activities    
Class of Stock [Line Items]    
Total net proceeds from financings 123,400  
Net proceeds used to date   123,400
March 2017 Offering | Working Capital and Corporate Purposes    
Class of Stock [Line Items]    
Total net proceeds from financings 38,924  
Net proceeds used to date   38,924
2018 Open Market Sale Agreement    
Class of Stock [Line Items]    
Total net proceeds from financings 28,830  
Net proceeds used to date   28,830
2019 Open Market Sale Agreement    
Class of Stock [Line Items]    
Total net proceeds from financings 14,371  
Net proceeds used to date   14,371
December 2019 Public Offering    
Class of Stock [Line Items]    
Total net proceeds from financings  
Net proceeds used to date  
December 2019 Public Offering | Pre-commercial and Launch Activities, Working Capital and Corporate Purposes    
Class of Stock [Line Items]    
Total net proceeds from financings 179,918  
Net proceeds used to date   44,181
July 2020 Public Offering    
Class of Stock [Line Items]    
Total net proceeds from financings 187,700  
Net proceeds used to date   0
July 2020 Public Offering | Research and Development Activities    
Class of Stock [Line Items]    
Net proceeds used to date   0
July 2020 Public Offering | Working Capital and Corporate Purposes    
Class of Stock [Line Items]    
Net proceeds used to date   0
July 2020 Public Offering | Pre- Commercial and Launch Related Activities    
Class of Stock [Line Items]    
Net proceeds used to date   $ 0
Minimum | July 2020 Public Offering | Research and Development Activities    
Class of Stock [Line Items]    
Total net proceeds from financings 28,000  
Minimum | July 2020 Public Offering | Working Capital and Corporate Purposes    
Class of Stock [Line Items]    
Total net proceeds from financings 10,500  
Minimum | July 2020 Public Offering | Pre- Commercial and Launch Related Activities    
Class of Stock [Line Items]    
Total net proceeds from financings 117,000  
Maximum | July 2020 Public Offering | Research and Development Activities    
Class of Stock [Line Items]    
Total net proceeds from financings 34,000  
Maximum | July 2020 Public Offering | Working Capital and Corporate Purposes    
Class of Stock [Line Items]    
Total net proceeds from financings 42,500  
Maximum | July 2020 Public Offering | Pre- Commercial and Launch Related Activities    
Class of Stock [Line Items]    
Total net proceeds from financings $ 143,000