Nature of expenses - Research and development (Details) - USD ($) $ in Thousands |
12 Months Ended | |
|---|---|---|
Dec. 31, 2018 |
Dec. 31, 2017 |
|
| Expenses by nature [abstract] | ||
| Contract research organizations (CROs) and other third party clinical trial expenses | $ 27,923 | $ 21,634 |
| Drug supply and distribution | 4,893 | 7,124 |
| Salaries, incentive pay and employee benefits | 4,260 | 3,065 |
| Stock compensation expense | 2,697 | 993 |
| Travel, insurance, patent annuity fees, legal fees and other | 1,609 | 1,114 |
| Research and development expense | $ 41,382 | $ 33,930 |
| X | ||||||||||
- Definition Research and development expense, drug supply and distribution No definition available.
|
| X | ||||||||||
- Definition Research and development expense, stock compensation expense No definition available.
|
| X | ||||||||||
- Definition Research and development expense, study contracts, consulting and other outside services No definition available.
|
| X | ||||||||||
- Definition Research and development expense, travel insurance, patent annuity fees and legal fees and other No definition available.
|
| X | ||||||||||
- Definition Research and development expense, wages and employee benefits No definition available.
|
| X | ||||||||||
- References No definition available.
|
| X | ||||||||||
- Definition The amount of expenditure directly attributable to research or development activities, recognised in profit or loss. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
|